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ea0065p366 | Reproductive Endocrinology and Biology | SFEBES2019

The effects of peptide-YY (PYY) on the reproductive axis in humans

Izzi-Engbeaya Chioma , Jones Sophie , Crustna Yoshibye , Machenahalli Pratibha , Papadopoulou Deborah , Modi Manish , Panayi Christos , Starikova Jessica , Eng Pei Chia , Phylactou Maria , Mills Edouard , Yang Lisa , Ratnasabapathy Risheka , Sykes Mark , Plumptre Isabella , Minnion James , Tharakan George , Tan Tricia , Veldhuis Johannes , Abbara Ali , Comninos Alexander , Dhillo Waljit

Introduction: Peptide-YY (PYY) is produced by intestinal L-cells following nutrient ingestion. PYY analogues are an emerging class of anti-obesity medication. Peripheral administration of PYY has potent anorectic effects in rodents and humans. Interestingly, rodent studies have demonstrated that PYY has additional effects on reproductive hormone secretion depending on the model studied. In humans, hypogonadism occurs in up to 40% of men with obesity. Therefore, the effects of ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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